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How the biggest Alzheimer’s risk gene disrupts the process of insulating neurons

MIT NewsBy David Orenstein | The Picower Institute for Learning and Memory

Brain cells called oligodendrocytes wrap neurons with a sheath of insulating fat called myelin to improve electrical conduction. In people carrying the APOE4 gene variant, which increases Alzheimer's risk, the cells accumulate lipid…

MIT researchers showed that the APOE4 gene variant suppresses molecular signaling needed for oligodendrocytes to myelinate neurons and also demonstrated a proof-of-concept fix.

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